Diisopropyl-fluorophosphatase as a Catalytic Bioscavenger

  • Hossein Allahyari Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran Iran
  • Ali Mohammad Latifi Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran Iran


Organophosphorus chemicals, used as pesticides and warfare nerve agent, are highly toxic compounds that inhibit acetylcholine esterase enzyme rapidly. A novel effective treatment for nerve gas poising is using of hydrolytic enzymes to degradation of these agents. DFPase from loligo vulgaris is highly stable and robust biocatalyst for the hydrolysis of various chemical warfare agents such as sarin, soman, tabun. Unfortunately, wild-type DFPase prefers less toxic isomers of these agents leading to slower detoxification. Also, due to non-human origin of the enzyme, immunological reactions occur when it injects into body. Engineering of the enzyme for creating of new efficient variants is an interesting research field which leads to occurrence of novel and prominent bioscavengers.


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How to Cite
ALLAHYARI, Hossein; LATIFI, Ali Mohammad. Diisopropyl-fluorophosphatase as a Catalytic Bioscavenger. Journal of Applied Biotechnology Reports, [S.l.], v. 3, n. 4, p. 477-482, june 2017. ISSN 2423-5784. Available at: <http://journals.bmsu.ac.ir/jabr/index.php/jabr/article/view/104>. Date accessed: 24 aug. 2017.
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DFPase; Bioscavenger; Organophosphate; Bioremediation

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