Relationship between Type 2 Diabetes and Depression: A Systematic Review

Masomeh Sardari, Marzieh Pazokian


Introduction: Type 2 diabetes is a metabolic disease that results in reduced quality of life, increased healthcare costs, and reduced life expectancy. Depression in diabetic patients reduces self-care and their performance abilities. The aim of this study was to investigate the relationship between type 2 diabetes and depression and the factors influencing them in studies in Iran and other parts of the world.

Materials and Methods: This research was a secondary systematic review study. The statistical population consisted of all the studies that examined type 2 diabetes and depression and the factors affecting them.

Results: After searching, screening and a qualitative evaluation of studies during the systematic review, the final synthesis was performed on 10 articles. The examination of the studies on the prevalence of depression showed that, on average, 42.13% of patients with diabetes are facing depression. The most important factors associated with depression in diabetes include high age and complications of diabetes, female gender, low income, and receiving oral or injectable diabetes drug.

Conclusion: Raising diabetic patients’ awareness regarding control and prevention of complications and making appropriate treatment and care interventions can prevent depression in patients. Screening diabetic patients for depression and factors affecting its incidence, as well as screening older patients with depression for diabetes, is also recommended in this regard.


Keywords: Type 2 Diabetes, Depression, Relationship

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